Marie-Luise Brezniceanu, Ph. D.

Chercheure adjointe, Faculté de médecine, Université de Montréal

m-l.brezniceanu@crhsc.rtss.qc.ca

Téléphone : 514 338-2222, poste 2487

Télécopieur : 514 338-2694

Formation et titres de compétences

• Ph. D. (biologie moléculaire/apoptose, Johann Wolfgang Goethe-Universität, Frankfurt, Allemagne, 2003
• M. Sc./DEA (national toxicologie des organes), Université Paris 7 (Denis Diderot), 1999

Domaine, thèmes et intérêts de recherche

Implication des voies moléculaires de la Vitamine D (en particulier à l’importance du CYP24a1) dans la sénescence, la sensibilisation à l’apoptose et la perte de fonction cellulaire dans les tubules proximaux rénaux durant le développement de la néphropathie diabétique.

Prix et distinctions

• 2006-2009 KRESCENT-CIHR fellow
• 2006 et 2008 CSN trainee award
  Prix d’excellence au CR-CHUM (2004 et 2008)

Publications

Rabenhorst U, Beinoraviciute-Kellner R, Brezniceanu ML, Joos S, Devens F, Lichter P, Rieker RJ, Trojan J, Chung HJ, Levens DL, Zörnig M. Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth Hepatology. 2009 Oct;50(4):1121-9.

Brezniceanu ML, Deroussent A., Mangold J.B., Schiller H., Gross G., Cresteil T. Oxidative metabolism of epothilone A and patupilone (epothiolone B) by cytochromes P450: involvement of CYP3A4 and CYP2C The Open Drug Metabolism Journal , 2008, 2,  pp. 14-23.

Liu F, Brezniceanu ML, Wei CC, Chénier I, Sachetelli S, Zhang SL, Filep JG, Ingelfinger JR, Chan JS. Overexpression of angiotensinogen increases tubular apoptosis in diabetes. J Am Soc Nephrol. 2008 Feb;19(2):269-80. Epub 2007 Dec 5.

Brezniceanu ML, Liu F, Wei CC, Chénier I, Godin N, Zhang SL, Filep JG, Ingelfinger JR, Chan JS. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes. 2008 Feb;57(2):451-9. Epub 2007 Oct 31.

Brezniceanu ML, Liu F, Wei CC, Tran S, Sachetelli S, Zhang SL, Guo DF, Filep JG, Ingelfinger JR, Chan JS. Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int. 2007 May;71(9):912-23. Epub 2007 Mar 7.

Brezniceanu ML, Wei CC, Zhang SL, Hsieh TJ, Guo DF, Hébert MJ, Ingelfinger JR, Filep JG, Chan JS. Transforming growth factor-beta 1 stimulates angiotensinogen gene expression in kidney proximal tubular cells. Kidney Int. 2006 Jun;69(11):1977-85.

Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int. 2006 Mar;69(6):1016-23.

Hsieh TJ, Chen R, Zhang SL, Liu F, Brezniceanu ML, Whiteside CI, Fantus IG, Ingelfinger JR, Hamet P, Chan JS. Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling. Kidney Int. 2006 Mar;69(6):1005-15.PMID: 16528250.

Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas.Völp K, Brezniceanu ML, Bösser S, Brabletz T, Kirchner T, Göttel D, Joos S, Zörnig M. Gut. 2006 Feb;55(2):234-42. Epub 2005 Aug 23.

Brezniceanu ML, Völp K, Bösser S, Solbach C, Lichter P, Joos S, Zörnig M. HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma. FASEB J. 2003 Jul;17(10):1295-7. Epub 2003 May 20.